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In different brain areas, there is a differential expression of mitochondrial ERα and ERβ variants suggesting that they can participate in several functions in the brain during aging (Alvarez-Delgado et al., Sirtuin 3 Pathway The function of the sirtuin family consisting of seven members is important in different aspects of cellular regulation such as lipid homeostasis and metabolism (reviewed Houtkooper et al., 2013) and oxidative stress management (reviewed in Rajendran et al., 2011)

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doi: 10.3390/nu10111738